Formula Optimization of 5-Aminosalicylic Acid Enema In Situ Gel by Factorial Design/Response Surface Methodology
- VernacularTitle:因子设计-效应面法优化5-氨基水杨酸原位凝胶灌肠液处方
- Author:
Lijun PENG
;
Xudong FU
;
Qian ZHAO
;
Lihong ZHOU
- Publication Type:Journal Article
- Keywords:
5-Aminosalicylic acid;
In situ gel;
Enema;
Factorial design;
Response surface methodology
- From:
China Pharmacist
2016;19(2):287-289,305
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the formula of 5-aminosalicylic acid enema in situ gel. Methods:5-Aminosalicylic acid ene-mas in situ gel was prepared using a cold dissolution method with carbomer as the gel matrix and xanthan gum as the thickener. A 32 full factorial design was used to investigate the effects of the concentrations of carbomer and xanthan gum on the viscosity before and af-ter the gelling, duration of inversion tube and sedimentation rate. Response surface methodology was used to optimize the formula. Re-sults:The quantitative relationships between the two factors and the four evaluation indices were obtained. The optimum formula was as follows:the concentration of carbopol and xanthan gum in the enema was 0. 7% and 0. 15%, respectively. The viscosity before and af-ter the gelling was 500-1 000 mPa·s and 2 200-2 700 mPa·s, respectively. The duration of inversion tube test was 40-80 min and the sedimentation rate was more than 98. 5%. Conclusion:The multi-objective simultaneous optimization of the formula of 5-aminosal-icylic acid enema in situ gel is accomplished by factorial design and response surface methodology.