Retrospective Study on the Correlation of Flurbiprofen Axetil Injection and Atrial Fibrillation in Elderly Patients after Cardiac Operation
- VernacularTitle:老年患者心脏手术后注射氟比洛芬酯与心房颤动相关性的回顾性研究
- Author:
Xiaofeng PAN
;
Linfeng HE
- Publication Type:Journal Article
- Keywords:
Cardiac surgery;
Flurbiprofen axetil injection;
Atrial fibrillation;
Fentanyl;
Retrospeltire study
- From:
China Pharmacist
2016;19(2):314-315,316
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between flurbiprofen axetil injection and atrial fibrillation in the elderly pa-tients after cardiac surgery and underlying mechanism. Methods: A retrospective research method was applied, and the medical re-cords of 62 elderly patients with cardiac surgery were chosen and divided into the experimental group and the control group according to the different medication. After the heart surgery, fentanyl was used in the control group, and flurbiprofen was applied in the experimen-tal group. Before and after the treatment, the serum C-reactive protein levels, the incidence of postoperative atrial fibrillation, postop-erative atrial fibrillation duration, length of stay, incidence of cardiovascular disease in 6 months and adverse reactions were observed and compared between the two groups. Results:After the treatment, the serum CRP levels in the experimental group were significantly lower than those before the treatment and those in the control group after the treatment (P<0. 05 or P<0. 01). The incidence of post-operative atrial fibrillation in the experimental group was significantly lower than that in the control group (P<0. 05). The duration of postoperative atrial fibrillation in the experimental group was significantly shorter than that in the control group (P<0. 05). The differ-ences in the postoperative hospital stay, the incidence of cardiovascular disease in six months and the incidence of adverse reactions were not statistically significant between the two groups (P>0. 05). Conclusion: Flurbiprofen axetil injection used after cardiac sur-gery can reduce the incidence of atrial fibrillation, which shows important clinical significance.
