A Clinical Study on Coenzyme Q10(Neuquinon(R)) in the Treatment of Congestive Heart Failure.
10.4070/kcj.1979.9.1.17
- Author:
Jeong Hyun KIM
;
Jong Yoon LIM
;
Yun Shik CHOI
;
Jung Don SEO
;
Young Woo LEE
- Publication Type:Original Article
- MeSH:
Blood Pressure;
Estrogens, Conjugated (USP)*;
Female;
Golgi Apparatus;
Heart;
Heart Failure*;
Heart Rate;
Humans;
Hypertension;
Membranes;
Mitochondria;
Research Design;
Ubiquinone
- From:Korean Circulation Journal
1979;9(1):17-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Coenzyme Q is concentrated in Golgi apparatus membranes and mitochondria, but not in other membranes. Although it is difficult to prove the metabolic action of coenzyme Q administered exogenously in clinical cases, the effect of this substance can be evaluated by criteria based on clinical findings. In an attempt to evaluate the effect of coenzyme Q for the treatment of 67 patients(male 26 cases, female 41 cases) of congestive heart failure, we administered Coenzyme Q1030mg daily for 4 to 8 weeks. Most of them were valvular heart disease(74.6%) and hypertension (14.9%). Clinical effects were evaluated at least 4 weeks later by the criteria using a scoring method of severity of congestive heart failure which was devised by Ishiyama, etc. In summary, a definite effect was found in 13 cases(19%) and a mild effect was observed in 46 cases(69%). During treatment there were no significant side effects, and also no significant changes in heart rate and blood pressure.
