Preliminary study of adiponectin receptor Ⅰ gene polymorphisms and polycystic ovary syndrome
10.3760/cma.j.issn.1008-1372.2015.08.017
- VernacularTitle:脂联素受体1基因多态性和多囊卵巢综合征的初步研究
- Author:
Jinchuan FANG
;
Yanni ZHOU
;
Liping LI
;
Sufang JIN
;
Xiaomei ZHOU
- Publication Type:Journal Article
- Keywords:
Receptors,adiponectin/GE;
Polycystic ovary syndrome/GE
- From:
Journal of Chinese Physician
2015;17(8):1179-1182,1186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation of the adiponectin receptor 1 gene rs1139646C/G and rs10920531C/A single nucleotide polymorphisms with Chinese Han women with polycystic ovary syndrome (PCOS).Methods For PCOS group (n =80) and control group (n =80),polymerase chain reaction (PCR) was used to amplify the upstream and downstream 250 bases of rsl139646C/G and rs10920531C/A,respectively.PCR products were directly sequenced.Results For rs1139646C/G loci sites between PCOS and control groups,all were the homozygous genotype CC,and no statistical significance was found for genotype frequency and allele frequency between two groups.For rs10920531C/A loci sites between PCOS and control groups,no statistical significance was found for genotype frequency and allele frequency between two groups (P =0.683,0.580),and no statistical significance was found for two loci with genetic linkage disequilibrium analysis (x2 =0.307,Fisher 's P =0.579610,Pearson' s P =0.579608).Conclusions Adiponectin receptor 1 gene rs1139646C/G and rs10920531C/A single nucleotide polymorphisms have nothing to do with Chinese Han PCOS women.Genetic linkage disequilibrium analysis has nothing to do with PCOS.The rs1139646C/G in Chinese Han population is relatively stable site,and no locus mutation is found.
