Relationship between molecular phenotype of ductal carcinoma in situ and that of invasive ductal carcinoma of the breast
10.13315/j.cnki.cjcep.2015.08.009
- VernacularTitle:乳腺导管内癌与浸润性导管癌分子表型的关系
- Author:
Jian CHEN
;
Ru TIAN
;
Yi LIU
;
Hongmei DONG
;
Ruifeng GUO
;
Huayin LIANG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
ductal carcinoma in situ;
invasive ductal carcinoma;
immunophenotyping
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(8):877-879,884
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the relationship between molecular phenotype of ductal carcinoma in situ ( DCIS) and that of inva-sive ductal carcinoma ( IDC) of the breast. Methods Immunohistochemical method was used to detect ER, PR, HER-2 and CK5 ex-pression in 165 cases of breast cancer, with DCIS and IDC existed in every one of the samples. Results In the 165 cases of breast cancer, the ER, PR, HER-2 and CK5 expression of IDC was positively correlated with that of DCIS, respectively. To evaluate IDC phenotype, the number of basal phenotype was 18 (10. 9%), HER-2-overexpression 20 (12. 1%), luminal A 102 (61. 8%), lumin-al B 20 (12. 1%), null phenotype 6 (3. 6%);to evaluate DCIS phenotype, the number of basal phenotype was 19 (11. 5%), HER-2-overexpression 20 (12. 1%), luminal A 104 (63%), luminal B 17 (10. 3%), null phenotype 5 (3%). 157 cases (95. 2%) of IDC had the same phenotype with DICS, but the rest 8 cases (4. 8%) not, three cases of luminal A DCIS transformed into one HER-2-overexpression and two null phenotype IDC, three of HER-2-overexpression DCIS transformed into luminal B IDC, one null pheno-type DCIS transformed into one luminal A IDC, and one basal phenotype DCIS transformed to HER-2-overexpression IDC. Conclusion Most of IDC have the same phenotype with DCIS, but there exist small part of DCIS which could transform into other phenotype IDC.
