Role of lipase in patients with acute pancreatitis

VernacularTitle:脂肪酶在急性胰腺炎诊治过程中的作用
Author: Zhili JI ; Wei SHI ; Feng QIU ; Haitao SUN ; Wei HAN ; Zhongtao ZHANG
Publication Type:Journal Article
Keywords: Pancreatitis; Lipase; Inflammation
From: International Journal of Surgery 2015;42(6):383-387,封3
CountryChina
Language:Chinese
Abstract: Objective To study the role of lipase in inflammation in patients with acute pancreatitis.Methods Acute pancreatitis patients (n =200) were enrolled in the study.The patients were examined by computerized tomography and the severity of AP is determined by Blathazat Score.We assess the muhivariate-adjusted association of amylase and lipase with inflammatory markers of AP.We identified that lipase was more specifically correlated with AP progression than amylase,lactate dehydrogenase and creatitine kinase.Results We demonstrated that in AP patients,a doubling of lipase excretion was associated with 6.8％ increase of white blood cells (95％ CI,3.06％-10.5％,P ＜ 0.01),10.3％ (95％ CI,5.7％-14.9％,P ＜ 0.01) increase of neutrophil number but 14.8％ (95％ CI,2.3％-27.3％,P ＜0.05) decrease of lymphocytes in the blood,respectively.By contrast,amylase has no association with these cells.Both amylase and lipase had no relationship with triglyceride level in AP patients.Conclusions Lipase serves as an indicator for the severity and treatment of AP.