Effect on the level of T cells immunity and mechanism of apoptosis in the Oral lichen planus patients induced by the total paeony glycoside
10.3969/j.issn.1671-8348.2015.26.007
- VernacularTitle:赤芍总苷诱导扁平苔藓中T细胞免疫和凋亡机制的研究
- Author:
Xia YANG
;
Jiyan HUANG
;
Ming WANG
;
Xuerong XIANG
;
Jieyi LI
;
Xingqi ZENG
;
Conghua LI
- Publication Type:Journal Article
- Keywords:
total paeony glycoside;
oral lichen planus;
cells immunity;
cells apoptosis
- From:
Chongqing Medicine
2015;(26):3622-3624,3627
- CountryChina
- Language:Chinese
-
Abstract:
Objective Observe the effect of Total paeony glycoside(TPG)has on the T-cell immune action and apoptosis process of Oral lichen planus patients and analyze the mechanism.Methods 20 OLP patients are recruited into this experiment, each is treated with TPG,and their clinical effect is taken notes of.Observe the apoptosis of OLP lesions from each of the patients before and after the treatment,compare the apoptosis condition and the expression of CD4 + ,CD8 + ,and the CD4 +/CD8 + ratio,to analyze the role TPG plays on the immune expression of T-cell and the effect on apoptosis process.Results TPG improve the clini-cal manifestation of OLP patients significantly,resulting in the decrease of reticulum and erosive areas,and the pain index is de-creased obviously.The expression of CD4 + and CD8 + are decreased in OLP lesions after the treatment of TPG.Conclusion TPG may induce the apoptosis of the T-cell in lamina propria of the OLP lesions to regulate the T-cell immune action of OLP patients, and slow the development of inflammatory process of OLP,and in that way,TPG shows its potential in treating OLP,and this ex-periment can provide the primary evidence.
