The screen of serum microRNA in Ⅳand Ⅳ+Ⅴ lupus nephritis patients
10.3969/j.issn.1671-8348.2015.27.001
- VernacularTitle:Ⅳ和Ⅳ+Ⅴ型狼疮性肾炎患者血清microRNA标志物的芯片初筛?
- Author:
Zhiheng ZHANG
;
Hongbo XIAO
;
Qi WANG
;
Yan WANG
;
Zuying XIONG
- Publication Type:Journal Article
- Keywords:
lupus nephritis;
renal pathology;
microRNAs;
microRNA array
- From:
Chongqing Medicine
2015;(27):3745-3747,3751
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminary screen serum microRNA which was related to class Ⅳ and class Ⅳ+Ⅴ lupus nephritis (LN)by using microRNA array technology,and explore the role of serum microRNA in renal pathological classification of lupus nephritis.Methods Eight serum samples of lupus nephritis patients from biological specimen library in our hospital were enrolled. Experimental group was composed of 4 class Ⅳ cases and 4 class Ⅳ+Ⅴ cases,control group was composed of 4 healthy persons. MicroRNA array was used to screen the differentially expressing microRNA.Results There were part of same miRNA in class Ⅳand classⅣ+Ⅴ LN,among which expression of 22 miRNA were significantly different,29 miRNA of classⅣ was unique,3 miRNA of class Ⅳ+Ⅴ was unique.Conclusion Serum miRNA has a potential to serve as a biomarker to identify class Ⅳ and classⅣ+Ⅴlupus nephritis.
