The expression and clinical significance of miR-146a/133b in Xinjiang women with cervical lesion
10.3969/j.issn.1671-8348.2015.27.007
- VernacularTitle:新疆妇女宫颈病变组织 miR-146a/133b 的表达及临床意义
- Author:
Li MA
;
Cailing MA
;
Chang LU
;
Yanxia CHEN
- Publication Type:Journal Article
- Keywords:
uterine cervical neoplasms;
uyghur;
miR-146a;
miR-133b;
papilloma virus
- From:
Chongqing Medicine
2015;(27):3765-3767,3771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the different expression and clinical significance of miR-146a/133b in cervical tissue in uy-ghur and Han women in Xinjiang.Methods The relative expression of miR-146a/133b in paraffin embedding tissues of cervicitis, CIN and cervical cancer was detected by the RT-qPCR.And analyzed the clinical significance in the development of cervical cancer. Results Compared with cervicitis,the expression of miR-146a/133b increased significantly in CIN and cervical cancer(P <0.05). With the cervical lesion was aggravating,the expression level increased.In cervical cancer tissue,the expression of miR-146a were different between Uyghur and Han women(P <0.05).Marriage age<20 years old,tumor diameter≥4 cm,with HPV infection in cervical cancer tissue,miR-146a/133b had high expression (P <0.05).Conclusion MiR-146a/133b are involved in incidence and development of cervical cancer,they may become new prognostic and evaluating molecular markers in cervical cancer.
