The effect ofα-lipoic acid on the retinal expression level of VEGF in rats with diabetes mellitus and mechanism
10.3969/j.issn.1671-8348.2015.25.003
- VernacularTitle:α-硫辛酸对糖尿病大鼠视网膜 VEGF 表达的影响及机制
- Author:
Fuhua HU
;
Yujun XU
;
Lilin LIU
;
Jian JI
;
Rongguo YU
;
Xiaorong LI
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
α-lipoic acid;
vascular endothelial growth factor
- From:
Chongqing Medicine
2015;(25):3463-3465,3469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of α-lipoic acid on the retinal expression level of VEGF and diabetic retinopathy in rats with diabetes mellitus and mechanism.Methods Totally 72 Wistar rats were divided into 4 groups:12 (control group)in group A,24 in modeling group(group B),24 in group treated withα-LA(group C)and 12 in high-glucose(group D).Group B to group D were given 60 mg/kg STZ through intraperitoneal injection,rats in group C were given 100 mg/kg α-LA and rats in group D were given 5.0% glucose-solution.The body mass,FPG,FINS,HOMA-IR,expression level of VEGF,activity of SOD,GSH and IL-6 of 4 groups were compared by statistics.Results After 72 h,the FPG of group A was(4.57 ±0.1 5 )mmol/L,that of group B was (21.72±4.28)mmol/L,that of group C was(21.54±4.96)mmol/L and that of group D was(21.83±4.77)mmol/L,the difference had statistical significance (P <0.05).The body mass of group A was(210.5±5.2)g,that of group B was(21 1.2 ±5.7)g,that of group C was(209.8±5.8)g and that of group D was(208.7±3.4)g,the difference had no statistical significance (P >0.05).The body mass,FPG,FINS,HOMA-IR,expression level of VEGF,activity of SOD,GSH and IL-6 among 4 groups at 4 w,8 w and 12 w had statistical difference (P <0.05).After 12 w,the difference of GR stage among group B to group D had statistical significance (P <0.05).Conclusion α-LA can inhibit the expression of VEGF in rats with diabetes mellitus,which is related to its ability to re-duce the oxidative stress and inflammation reaction,as well as to alleviate the insulin resistance.
