Evaluation of anticancer efficacy of dihydromyricetin in gastric cancer cells SGC7901

VernacularTitle:二氢杨梅素对胃癌细胞 SGC7901生长活性及凋亡的影响
Author: Yanfang WU ; Yujie LU ; Jing JU
Publication Type:Journal Article
Keywords: apoptosis; gastric neoplasms; DMY
From: Chongqing Medicine 2015;(25):3485-3487,3490
CountryChina
Language:Chinese
Abstract: Objective To investigate the anticancer efficacy of dihydromyricetin (DMY)in gastric cancer cells SGC7901. Methods The DMY was puritied using RP-HPLC was almost 98%.The cell viability was assessed by CCK-8 Assay.The cell ap-optosis was assessed by flow cytometry.Using ultrasonic extraction with neutral water and reversed-phase high-performance liquid chromatography,DMY was purified from rattan tea.Results By using RP-HPLC,the purified DMY is almost 99%.DMY inhibi-ted the growth of tumor cells in the low concentration(≤ 1 mmol)with a dose-dependent manner(P <0.05 ).Further study on DMY showed that it induced apoptosis in SGC7901 cell line with a dose-dependent manner.Conclusion DMY is a potential thera-peutic agent for gastric cancer.