Clinical significance of CXCL10 and CXCR3 expression in patients with bladder neoplasm
10.3969/j.issn.1671-8348.2015.25.011
- VernacularTitle:趋化因子配体10及趋化因子受体3在膀胱癌中的表达及意义
- Author:
Xiaohui PENG
;
Peiyu LIANG
;
Shangji OU
;
Xiongbing ZU
- Publication Type:Journal Article
- Keywords:
bladder neoplasm;
chemokine CCL10;
receptors,CXCR3
- From:
Chongqing Medicine
2015;(25):3491-3492,3496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of CXCL10 and its receptor CXCR3 expression in bladder neoplasm and ex-plore their clinical significance.Methods Totally 80 patients with bladder neoplasm and 33 healthy control were recruited in this study.The serum level of CXCL10 was determined by ELISA and CXCR3 mRNA in peripheral blood mononuclear cell was meas-ured by RT-PCR.The relationship of serum CXCL10 and CXCR3 levels with clinical parameter were analyzed.Results The serum CXCL10 and CXCR3 levels in patients of bladder neoplasm were significantly higher than the control group(P >0.05).The serum CXCL10 and CXCR3 levels was significantly correlated with lymphatic metastasis (P <0.05).Conclusion High expression of CX-CL10 and CXCR3 may relate to bladder cancer and possibly correlate with lymphatic metastasis.
