Expression of TRPM7 protein in cholangiocarcinoma and its correlation with prognosis
10.3969/j.issn.1671-8348.2015.25.022
- VernacularTitle:TRPM7在胆管癌组织中的表达及其与预后的关系
- Author:
Li LI
;
Yuwen CAO
;
Hexing WU
;
Qikun WANG
;
Xiao CHU
;
Lin YANG
;
Jingxia TANG
;
Xinyu PENG
;
Shijie ZHANG
;
Hongqiang YANG
- Publication Type:Journal Article
- Keywords:
cholangiocarcinoma;
transient receptor potential melastatin 7;
neplasms stage;
neplasms metastasis
- From:
Chongqing Medicine
2015;(25):3523-3525,3528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of transient receptor potential melastatin 7(TRPM7)in cholangiocarcinoma and its correlation with prognosis.Methods The expressions of TRPM7 were detected by SP immunohistochemical in 49 cases of cholangiocarcinoma,7 cases of benign bile duct lesions and 36 cases of adjacent histologically noncancerous bile duct tissues,and to analysis its relationship with the clinical pathological characteristics of cholangiocarcinoma.Results The positive expression rate of TRPM7 in cholangiocarcinoma was 77.6%(38/49),which was higher than that in benign bile duct lesions(0,0/7)and adjacent his-tologically noncancerous bile duct tissues(2.8%,1/36),the difference was statistically significant(P <0.05).The positive expres-sion of TRPM7 in cholangiocarcinoma was correlated with the TNM stage of tumor,lymph node metastasis and organ metastasis (P <0.05),but not related to patients′age,gender,site,differentiation and hepatitis(P >0.05).Kaplan-Meier analysis showed that increased expression of TRPM7 was associated with shorted overall survival (P <0.05).Cox regression analysis showed that the expression level of TRPM7 was significantly associated with prognosis and an independent risk factor for prognosis(P <0.05 ). Conclusion TRPM7 plays an important role in the tumorigenesis progression,invasion,and metastasis of cholangiocarcinoma,and is an important factor for prognosis in patients with cholangiocarcinoma.
