Comparative study on curative effects of two traditional Chinese medicine compounds in guinea pigs models of vitiligo
10.3969/j.issn.1673-4130.2015.18.023
- VernacularTitle:不同中药复方治疗豚鼠白癜风模型疗效比较
- Author:
Xue JIANG
;
Siyu QIAN
;
Wenhao ZHENG
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine compound;
vitiligo;
melanocyte;
curative effect
- From:
International Journal of Laboratory Medicine
2015;(18):2672-2673,2676
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the curative effects of two traditional Chinese medicine compounds in guinea pigs models of vitiligo .Methods The dark skin of guinea pigs ,which were intragastrically administrated with vitiligo granules No .1 (No .1 group) ,vitiligo granules No .2(No .2 group) and pure water(control group) respectively ,were selected to establish vitiligo modles induced by p‐dihydroxy‐benzene(hydroquinone) .Taking physiological saline as a control(model group) .Curative effects were ob‐served by visual inspection ,and the effects of repigmentation after intragastric administration were scored .The melanocyte count of normal part of skin was compared with that of vitiligo skin by using hematoxylin‐eosin(HE) staining ,ferrous sulfate staining and Deoxy‐dyeing .Results The guinea pigs models of vitiligo were successfully induced by hydroquinone .After treatment by using vit‐iligo granules No .1 and No .2 ,the melanocyte counts of vitiligo skin in No .1 group and No .2 group were increased when compared with that in the control group(P<0 .05) ,while no significant differences were observed between the vitiligo skin and the normal part of skin in the guinea pigs models of vitiligo(P>0 .05) .Conclusion The two Chinese medicine compounds ,vitiligo granules No .1 and vitiligo granules No .2 ,both are effective for the treatment of vitiligo and without obvious effects on normal parts of skin , which could provide experimental data for clinical treatment .
