Study on relationship between serum CXC chemokine ligand 16 levels and the carotid atherosclerotic plaque in patients with acute cerebral infarction
10.3969/j.issn.1673-4130.2015.18.029
- VernacularTitle:血清CXC趋化因子配体16水平与急性脑梗死患者颈动脉粥样硬化斑块关系研究
- Author:
Jinfang WANG
- Publication Type:Journal Article
- Keywords:
CXC chemokine ligand 16;
C-reactive protein;
acute cerebral infarction
- From:
International Journal of Laboratory Medicine
2015;(18):2686-2687,2690
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum levels of CXC chemokine ligand 16(CXCL16) and carotid artery atherosclerosis in patients with acute cerebral infarction(ACI) .Methods A total of 36 cases of patients with ACI were enrolled in ACI group ,and 30 individuals received physical examination were enrolled into control group .Levels of blood lipid ,high‐sensitive C‐reactive protein(hs‐CRP) and serum CXCL16 were detected ,and the carotid atherosclerotic plaques and changes of carotid intimal‐medial thickness(IMT) were examined by using the Color Doppler ultrasonography .Results The serum levels of CXCL16 in ACI group[3 .58(1 .06 -12 .83)ng/L] was higher than that in control group[1 .57(0 .61 -3 .34)ng/L] ,had statistically significant difference(P<0 .05) .The carotid IMT were higher in ACI group[(1 .19 ± 0 .36)mm] than that in control group[(1 .01 ± 0 .18) mm] ,had statistically significant difference(P<0 .05) .In ACI group ,the serum level of CXCL16 was higher in patients with vul‐nerable plaques than that in patients with stable plaques ,had statistically significant difference(P<0 .05) ,Serum levels of CXCL16 were correlated with carotid IMT and levels of hs‐CRP(r=0 .497 ,P<0 .05 ;r=0 .442 ,P<0 .05) .Multiple linear stepwise regres‐sion analysis showed that CXCLl6 was one of the independent risk factors for the development of carotid atherosclerotic plaques . Conclusion High serum levels of CXCLl6 and hs‐CRP might be independent risk factors for the development of carotid atheroscle‐rotic plaques ,and CXCLl6 might be closely correlated to the vulnerability of carotid atherosclerosis plaques .
