Expression of Chemokine CXCL12 and Its Receptor CXCR4 in Endometrial Carcinoma Tissues
10.3969/j.issn.1671-7414.2015.04.005
- VernacularTitle:子宫内膜癌组织中趋化因子CXCL12及其受体 CXCR4表达水平研究
- Author:
Fuli ZHENG
;
Miao DANG
;
Miaofang ZHANG
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
endometrial carcinoma;
chemokine CXCL12;
receptors CXCR4
- From:
Journal of Modern Laboratory Medicine
2015;(4):21-23,27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the translations of chemokine CXCL12 and its receptor CXCR4 in endometrial carcinoma tissues,and to evaluate their significance in clinical pathologic features of endometrial carcinoma.Methods From Jan.2012 to Dec.2014,52 tissue specimens of patients with endometrial carcinoma were admitted to the hospital,aged 55.6 ± 19.2 years,and 26 cases of normal endometrium as control,aged 52.3±16.5 years old.Expressions of CXCL12 and CXCR4 in the tissue specimens were detected by immunohistochemistry,and to analyze the relationship between the expressions and clini-cal pathological features,and FIGO stage,cell differentiation,lymph node metastasis and pathological type in endometrial carcinoma.Results In endometrial carcinoma,the positivity rates of CXCR4 and CXCL12 were 76.92% and 69.23% re-spectively.The positive expression rates of which were 34.62% and 30.77% in normal endometrium tissues,statistically significant (χ2 =11.826,P <0.01).The expression of CXCR4 was positively correlated with the differentiation of endome-trial carcinoma cells (P <0.05).In endometrial carcinoma,with the exception of CXCR4 expression and cell differentiation was positively related (r=0.386,P <0.05),CXCL12 and CXCR4 expression and clinical stage,pathological type and lymph node metastasis no correlation was found (P >0.05).Conclusion The results showed that the expression of CXCL12 and CXCR4 in endometrial carcinoma tissues was significantly increased,which may play an important role in the development of endometrial cancer.
