Development of Crohn disease in patients with myelodysplastic syndrome: report of two children.
10.3345/kjp.2006.49.1.107
- Author:
Jeong Ok SHIM
1
;
Jeong Kee SEO
;
Hye Ran YANG
;
Jae Sung KO
;
Hee Young SHIN
;
Hyo Seop AHN
;
Woo Sun KIM
;
Gyeong Hoon KANG
Author Information
1. Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. jkseo@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Crohn disease;
Myelodysplastic syndrome;
Children
- MeSH:
Abdominal Pain;
Biopsy;
Cecum;
Child*;
Colon, Ascending;
Colonoscopy;
Crohn Disease*;
Diarrhea;
Exudates and Transudates;
Failure to Thrive;
Fever;
Gastrointestinal Hemorrhage;
Humans;
Incidence;
Inflammation;
Mesalamine;
Mucous Membrane;
Myelodysplastic Syndromes*;
Ulcer;
Vomiting
- From:Korean Journal of Pediatrics
2006;49(1):107-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
Crohn disease (CD) is rare, but the incidence of CD has been increasing over the past ten years. We found two cases of CD, associated with myelodysplastic syndrome (MDS), for the first time in children. In the first patient, MDS was diagnosed at three years of age and CD developed later at eight years of age. The patient presented with recurrent abdominal pain, diarrhea, bloody stools and failure to thrive. Colonoscopy revealed cobble stone like mucosa and mass like lesions with superficial ulceration and inflammatory exudates, observed from the cecum to ascending colon. Ileo-cecal biopsy samples showed ulcers with skipped areas and lymphoid infiltrations. The patient was started on treatment with mesalazine and deflazacort, and symptoms remitted. In the second patient, MDS was diagnosed at nine years of age and CD developed at 13 years of age. This patient has recurrent hematochezia, abdominal pain, vomiting and fever. Colonoscopy revealed a large, deep indurative ulceration on the cecal side of the ileo-cecal valve. Ileocecectomy was done, and histology revealed ulceration with transmural inflammation and lymphoid aggregates. Symptoms improved after ileocecectomy.
