Comparative study of curative effect and blood glucose and lipid in schizophrenic patients who treated with ziprasidone and risperidone
10.3969/j.issn.1673-4130.2015.17.007
- VernacularTitle:齐拉西酮与利培酮对精神分裂症患者的疗效及其对血糖血脂的影响
- Author:
Qiping LI
;
Ao ZHAO
;
Huiteng LI
;
Chunyang LI
;
Zaiping HUANG
;
Huanyu XU
;
Jieping GUAN
;
Tanling XIAO
;
Jinhua ZHANG
;
Zhanhong FU
- Publication Type:Journal Article
- Keywords:
ziprasidone;
risperidone;
blood glucose;
blood lipids;
schizophrenia
- From:
International Journal of Laboratory Medicine
2015;(17):2471-2472,2475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of ziprasidone and risperidone on patients with schizophrenia and their influence on bloodglucoseandlipids.Methods 96patientswithschizophrenicenrolledinthestudywererandomlydividedintotwogroups,zi‐prasidone and risperidone group ,and both were treated for 8 weeks .Their blood glucose ,blood lipid of base line and at the end of the 4th ,8th week were determined respectively .Results The positive and negative symptoms scores of the two groups by using Positive and Negative Syndrome Scale(PANSS) before and after treatment were not statistically different(P> 0 .05) .Compared with the baseline scores ,scores at the end of 4th and 8th week in both ziprasidone and risperidone groups significantly decreased(P<0 .05) ,but there was no statistically significant difference between the two groups(P>0 .05) .After 8 weeks′ treatment ,the ef‐fective rate was 91 .7% in ziprasidone groups and 89 .6% in risperidone group .There were no significant differences between the two groups(P>0 .05) .The blood lipids and glucose levels were less increased after ziprasidone treatment ,but was not statistically significant(P>0 .05) .The blood lipids and glucose levels significantly increased after risperidone treatment(P<0 .05) .Conclusion Ziprasidone and risperidone had the same effect on schizophrenia .Ziprasidone had no effect on blood glucose and lipids in schizo‐phrenic patients ,while risperidone could increase blood glucose and lipids level ,we should pay attention to the side effects of long‐term use .
