Effect of rubescens on inflammatory cytokines and liver function in rat with alcoholic liver injury model
- VernacularTitle:冬凌草对酒精性肝损伤模型大鼠炎性因子及肝功能的影响
- Author:
Qiwen SONG
;
Zhi LIU
;
Weimin SUN
;
Rong TAN
;
Yong HUANG
- Publication Type:Journal Article
- Keywords:
alcoholic liver injury;
rubescens;
transaminase;
inflammatory cytokines
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):15-17,21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effect of rubescens on inflammatory cytokines and liver function of alcoholic liver injury rat model.Methods 120 SD rats were chosed for studied, randomly divided into control group, model group and treatment group,40 rats per group.Alcoholic liver injury rat model was made by ethanol feeding approach, rubescens were given for treatment.Then serum AST, ALT, α-GST, GLDH content and liver tissue NF-κB, TNF-α, IL-6, IL-8 levels were detected by electrochemiluminescence and fluorescent quantitation PCR,respectively.Results Model group serum AST, ALT,α-GST, GLDH contents and NF-κB, TNF-α, IL-6, IL-8 contents in liver tissue were higher than control group(t=12.030~37.417, P<0.05). Treatment group serum AST,ALT, α-GST, GLDH contents and NF-κB, TNF-α, IL-6, IL-8 contents in liver tissue were lower than model group (t=5.128~32.325, P<0.05).Conclusion Alcohol feeding can cause liver damage, rubescens therapy can reduce liver injury, relieve inflammation.
