Effect of propofol on perioperative inflammatory response in patients with lung cancer
- VernacularTitle:丙泊酚对肺癌患者围术期炎性反应的影响
- Author:
Jinyu HAN
;
Hongwei ZHAO
- Publication Type:Journal Article
- Keywords:
propofol;
sevoflurane;
lung cancer;
perioperative period;
inflammatory response
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):68-69,72
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of propofol total intravenous anesthesia and sevoflurane inhalation anesthesia on perioperative inflammatory response in patients with lung cancer.Methods Forty patients with simple resection of lung cancer were selected in our hospital.They were divided into observation group and control groups according to random sampling method (n=20).Observation group was given propofol total intravenous anesthesia while control group received sevoflurane inhalation anesthesia.The serum concentrations of MMP-9,TNF-α,IL-6 were compared at the T0 (immediately before the induction of anesthesia) , T1 (1 hour after surgery) , T2 (end of the surgery immediately) , T3 (24 hour after surgery) . Results Compared with the T0 period,the serum concentrations of MMP-9,TNF-αand IL-6 at the T1,T2,T3 periods were increased significantly in the both groups(P<0.05);the concentrations of TNF-α, IL-6 were lower significantly in observation group compared with control group (P<0.05) . Conclusion Propofol anesthesia for resection of lung cancer patients can significantly reduce the inflammatory response.
