Effect of citalopram on IL-6 , BDNF and cortisol on patients with depression syndrome
- VernacularTitle:西酞普兰对抑郁症患者白细胞介素-6、脑源性神经生长因子及皮质醇的影响
- Author:
Feng TAO
;
Xiaofei SUN
- Publication Type:Journal Article
- Keywords:
citalopram;
depressive syndrome;
interleukin-6;
brain derived neurotrophic factor;
cortisol
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):59-60,64
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of citalopram on interleukin-6 (IL-6) and brain derived neurotrophic factor (BDNF) in serum and cortisol in plasma of patients with depression syndrome.Methods 60 patients with depression in Kangci Hospital of Jiashan were randomly divided into two groups.31 cases in experimental group were treated with citalopram, 29 cases in control group were treated with imipramine.Levels of IL-6 and BDNF in serum and cortisol in plasma were compared pre-and post-treatment between two groups.Results Compared with pre-treatment, the levels of IL-6 and cortisol were lower(P<0.05), the level of BDNF was higher(P<0.05) post-treatment in two groups.Compared with control group, the levels of IL-6 and cortisol were lower(P<0.05), the level of BDNF was higher(P<0.05)in experimental group.Conclusion Citalopram has good curative effect on depression.The mechanism may be related to the decrease of IL-6 and cortisol levels, and the increase of brain derived neurotrophic factor level.
