Effect of long-term inhaled corticosteroids on growth indicatorsin children with bronchial asthma
- VernacularTitle:长期吸入糖皮质激素对支气管哮喘患儿生长指标的影响
- Author:
Wenzhong NIU
;
Xianchun DING
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
long-term;
inhaled corticosteroids;
growth;
children
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;35(10):108-109,112
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of long-term inhaled corticosteroids on insulin-like growth factor-1(IGF-1),bone mineral density, height and weight in children with bronchial asthma.Methods Bronchial asthma were selected as treatment group from January 2013 to January 2014 in pediatrics department of Nanyang Central Hospital, and 25 healthy children undergoing physical examination at the same time were selected as control group.All children aged from 4 to 5 years old.The treatment group received nebulized budesonide suspension, 250-1 000μg per time, two times per day and 10-15 min per time for a maintenance therapy of 12 months.The control group were without any treatment.The changes of IGF-1 and bone mineral density were compared among pre-treatment, 6 months and 12 months post-treatment in treatment group and the changes of height and weight were compared between two groups.Results There were no significant differences in levels of serum IGF-1 and bone mineral density among pre-treatment, 6 months and 12 months post-treatment in treatment group (F =0.259,F =0.217, all P>0.05).There were no significant differences in height and weight between two groups pre-treatment, 6 months and 12 months post-treatment.Conclusion Long-term inhaled corticosteroids has no significant effect on growth indicators in children aged 4-5 years old with bronchial asthma.
