Analysis of the correlation between three evaluation methods of rat models of focal cerebral ischemia/reperfusion

VernacularTitle:大鼠局灶性脑缺血模型评价方法间关联性分析
Author: Xuran CUI ; Zhao LIU ; Zhibin ZHANG ; Juying ZHONG
Publication Type:Journal Article
Keywords: Infarct area; Behavioral score; Cerebral blood flow; Rats
From: Acta Laboratorium Animalis Scientia Sinica 2015;23(5):506-508,512
CountryChina
Language:Chinese
Abstract: Objective To analyze the correlation between three evaluation methods of middle cerebral artery occlu -sion and focal cerebral ischemia , and to explore a new method and standard for the evaluation of the model .Method Thirty healthy adult male SD rats were randomly divided into a sham-operated group ( n=20 ) and model group .According to Zea-Longa procedure ,we established the disease model to detect the changes in cerebral blood flow before and after sur -gery.The resulted cerebral infarction area was taken as gold standards .Then we analyzed the correlation between the standards and the changes in cerebral blood flow .Results The changes of infarction area ratio were positively correlated with the changes of cerebral blood flow in the model rats .Conclusions The changes of rat cerebral blood flow can be used to evaluate whether the cerebral ischemia model is successful or not .