Effect of stanozolol on the nitrogen balance,grip strength and clinical outcomes of critical patients with high nutrition risk
10.3969/j.issn.1671-8348.2015.30.014
- VernacularTitle:司坦唑醇对高营养风险危重患者氮平衡、握力及临床预后影响的研究
- Author:
Yuhui WANG
;
Dali LONG
;
Baning YE
;
Xianqing SHI
- Publication Type:Journal Article
- Keywords:
stanozolol;
critically ill patients;
nitrogen balance;
grip strength
- From:
Chongqing Medicine
2015;(30):4216-4218,4221
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of stanozolol on nitrogen balance ,grip strength and clinical outcomes of criti‐cal patients with high nutrition risk .Methods We enrolled patients who were admitted to the ICU of Guizhou provincial Hospital during the time period from January 2014 to June 2014 and ,as patients with high nutrition risk .Patients ,who received same base nutritional support program ,were divided into two groups .Treatment group who were treated with stanozolol administrated with gastric or jejunal tube for 7 days by 4 mg Tid .The control group whose members underwent placebo simultaneously with the treat‐ment group .The nitrogen balance ,grip strength of both groups was measured when at admitted and 4th as well as 7th day .Prealbu‐min ,total bilirubin ,alanine aminotransferase ,and aspartate aminotransferase were measured when at the same time and before leave hospital .The duration of the mechanical ventilation ,ICU stays ,hospital stays and mortality within 28 days were recorded .Results There was no statistical significance in the differences between all the indicators of the two groups at admission(P>0 .05) .The du‐ration of mechanical ventilation ,ICU stays ,hospital stays were decreased significantly in the treatment group (P<0 .05) compared to the control group .But the mortality within 28 days had no significant difference between two groups (P>0 .05) .Nitrogen bal‐ance ,prealbumin ,grip strength and liver function parameters in the treatment group were significantly higher than they were been at admitted and control group at 4th and 7th day (all P<0 .05) .Liver function parameters of treatment group gradually decreased to the normal range before discharge .Conclusion In critically ill patients treated with anabolic steroid stanozolol ,can promote protein synthesis ,reduce muscle and other lean tissue decomposition ,improve clinical symptoms ,short the length of hospital stay and ICU stay .But we should pay more attention on liver function in critically ill patients who treated with stanozolol .
