Effects of inhaled corticosteroids in children with persistent asthma on growth:a Meta-analysis
10.3969/j.issn.1671-8348.2015.30.021
- VernacularTitle:吸入糖皮质激素对哮喘儿童身高影响的 Meta分析
- Author:
Ying LI
;
Guangli ZHANG
;
Hui ZHANG
;
Junqi LI
;
Dongwei ZHANG
;
Ru LIU
;
Zhengxiu LUO
- Publication Type:Journal Article
- Keywords:
asthma;
child;
Meta-analysis;
inhaled corticosteroids
- From:
Chongqing Medicine
2015;(30):4234-4238,4243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of inhaled corticosteroids on growth velocity in children with asthma .Methods We searched the Cochrane Airways Group Specialised Register of trials (CAGR) ,which was derived from systematic searches of bibliographic databases including CENTRAL ,MEDLINE ,EMBASE ,CINAHL ,AMED and PsycINFO .We also searched Wan Fang Chinese periodical Database and VIP Chinese periodical Database from the establishment of the database to October 2014 .Articles which were parallel‐group randomised controlled trials comparing daily used of ICS ,delivered by any type of inhalation device ,ver‐sus placebo or non‐steroidal drugs in children up to 18 years of age with persistent asthma are selected .The data analysis was used by RevMan 5 .2 software .Results A total of 18 randomized control trials were included .Meta analysis showed that inhaled cortico‐steroids for 6-8 months ,1 year significantly slowing down growth velocity in children with asthma (MD= -0 .77 ,-0 .55 ,respec‐tively ,P<0 .01) .Inhaled corticosteroids for 2 years had no significant inhibition on growth velocity in children with asthma (MD=-0 .30 ,P>0 .05) .Conclusion This systematic review showed that ICS therapy had temporarily inhibition on growth velocity in children with asthma ,the peak inhibition happen within half a year ,its inhibitory effect decrease with time .
