The influence of pretreatment with PPI on helicobacter pylori eradication:a Meta analysis
10.3969/j.issn.1671-8348.2015.30.023
- VernacularTitle:预先使用质子泵抑制剂对幽门螺杆菌根除率影响的M eta分析
- Author:
Jia CHEN
;
Chuanfei LI
;
Lin LV
;
Zhechuan MEI
- Publication Type:Journal Article
- Keywords:
proton pump inhibitors;
helicobacter pylori;
eradication rate;
Meta-analysis
- From:
Chongqing Medicine
2015;(30):4244-4246,4251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To systematically investigate the pretreatment impact of proton pump inhibitor (PPI) on Helicobacter pylori (HP) eradication rate .Methods PubMed ,EMBASE ,Cochrane database ,Web of Science ,Clinical trial .gov ,SinoMed ,China National Knowledge Internet ,WANFANG Data ,VIP database and Google Scholar were used to search for randomized controlled trials(RCT) .HP eradication rate was calculated by per‐protocol analysis (PP) .RevMan 5 .2 was applied to analyze data .Results There were 10 articles included (982 cases) ,43 cases didn′t meet the program have been removed ,a total of 939 cases included .The result showed that there was no significant difference between the pretreatment of PPI group and the control group ,RR= 0 .99 (95% CI:0 .95-1 .04 ,P=0 .75) .Conducted a subgroup analysis according to eradication regimen ,regimen combining a PPI ,amoxi‐cillin and clarithromycin and regimen combining a PPI ,clarithromycin and metronidazole the pooled risk ratio were 1 .02(95% CI:0 .90-1 .14 ,P=0 .79)and 1 .02(95% CI:0 .92-1 .12 ,P=0 .74)respectively ,there were no significant difference as well .Conclusion The pretreatment with PPI does not affect HP eradication rates of triple or quadruple therapies for HP eradication .We can eradi‐cate HP directly for the patients who have used PPI but were diagnosed to be positive to HP .
