Effect of shenqifuzheng injection on CX3CR1 in colonic mucosa of patients with ulcerative colitis
10.3969/j.issn.1671-8348.2015.29.022
- VernacularTitle:参芪扶正注射液对溃疡性结肠炎患者大肠黏膜CX3CR1的影响
- Author:
Changdong ZHAO
;
Xiaojie ZHANG
;
Lei ZHANG
;
Hongbo LUO
;
Xian CHEN
;
Hui ZHANG
;
Yifeng ZHANG
- Publication Type:Journal Article
- Keywords:
colitis,ulcerative;
intestinal mucosa;
shenqifuzheng injection;
CX3CR1
- From:
Chongqing Medicine
2015;(29):4095-4097,4101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of shenqifuzheng injection combined with sulfasalazine (SASP) in the treatment of ulcerative colitis (UC) ,and to evaluate the effect of CX3CR1 on colonic mucosa of UC in treatment with shenqifuzheng injection .Methods Fifty‐one patients with active mild to moderate UC were collected during the period from January 2012 to June 2014 in the second people′s hospital of Lianyungang ,which randomly divided into experimental group and control group ,and setting up health group of 15 cases .Experimental group were treated with shenqifuzheng injection combined with SASP ,control group were only with SASP ,health group were no‐treatment control .The modified Mayo scoring results and the expression of CX3CR1 on co‐lonic mucosa of the same lesion site were observed before and two weeks after treatment separately .Results The total positive rate of CX3CR1 on colonic mucosa in patients with ulcerative colitis was 88 .37% before treatment ,The total positive rate of CX3CR1 on colonic mucosa in health group was 20 .00% ,There was significant difference between two groups (Z= -2 .689 ,P<0 .01) .Two weeks after treatment ,the expression of CX3CR1 on colonic mucosa and the modified Mayo scoring results in the experimental group were significantly lower than those in the control group (P<0 .05) .The clinical comprehensive efficacy of the experimental group was significantly better than the control group (Z= -2 .085 ,P<0 .05) .Conclusion Combination of shenqifuzheng injection and SASP is more effective than using SASP alone in the treatment of UC .Shenqifuzheng injection may play important role in the treatment of UC by inhibiting the expression of CX3CR1 on colonic mucosa .
