The value of Golgi protein 73 detection combined with alpha-fetoprotein,α-L-fucosidase,α-antitrypsin in the diagnosis of primary liver cancer
10.3969/j.issn.1673-4130.2015.20.010
- VernacularTitle:高尔基体蛋白73联合甲胎蛋白、α-L 岩藻糖苷酶、α-抗胰蛋白酶检测对原发性肝癌的诊断价值
- Author:
Hua HUANG
;
Hongmei LIANG
;
Hui XU
;
Tingxiong ZHOU
;
Jianwei WANG
- Publication Type:Journal Article
- Keywords:
primary hepatic carcinoma;
golgi protein 73;
alpha-fetoprotein;
α-L-fucosidase;
α-antitrypsin
- From:
International Journal of Laboratory Medicine
2015;(20):2945-2946,2949
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnostic value of the golgi protein 73 (GP73) combined with alpha‐fetoprotein (AFP) ,α‐L‐fucosidase (AFU) andα‐antitrypsin(α‐AT) detection in primary hepatic carcinoma(PHC) .Methods 100 patients with PHC ,100 patients with hepatitis and cirrhosis ,and 100 healthy people hospitalized in the hospital from October 2011 to May 2013 were en‐rolled in the study .Serum AFP levels were detected by using Beckman DxI800 chemiluminescent analyzer ,serum AFU ,α‐AT levels were detected by using Beckman DxC800 automatic biochemical analyzer ,and GP73 levels were measured by using enzyme‐linked immunosorbent GP73 quantitative detection kits .Results In patients with PHC and patients with hepatitis and cirrhosis ,serum GP73 ,AFP ,AFU ,α‐AT levels were significantly higher than healthy people(P<0 .05) .In patients with PHC ,GP73 ,AFP ,AFU ,α‐AT levels were significantly higher than those in patients with hepatitis and cirrhosis(P<0 .05) .The sensitivities of single serum GP73 ,AFP ,AFU ,α‐AT detection were 75% ,72% ,23% ,67% respectively and specificity were 95% ,95% ,100% ,97% respective‐ly .The sensitivity and specificity of the 4 tumor markers′combined detection were 99% and 100% .The sensitivity of combined de‐tection was significantly different from single detection(P<0 .05) .Conclusion GP73 ,AFP ,AFU ,α‐AT may improve the diagnostic efficiency of primary liver cancer .
