Associations of fibrinogen genetic variation rs1049636 withγ′fibrinogen level and ischemic stroke
10.3969/j.issn.1673-4130.2015.20.005
- VernacularTitle:纤维蛋白原基因多态性位点与血浆纤维蛋白原γ′水平及缺血性脑卒中的关系研究
- Author:
Shanshan YU
;
Yuanyuan DING
;
Ming ZONG
;
Hui ZHANG
;
Hanqi WANG
;
Qi TAN
;
Lieying FAN
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
γ′fibrinogen;
single nucleotide polymorphism
- From:
International Journal of Laboratory Medicine
2015;(20):2932-2933,2936
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between fibrinogen gene polymorphism(rs1049636) and serum γ′ fibrinogen level and ischemic stroke (IS) .Methods 421 IS patients and 421 age‐and gender‐ matched healthy controls ,including 283 males and 138 females ,were recruited in this assay .The plasma γ′fibrinogen concentration was measured by enzyme‐linked immunosor‐bent assay (ELISA) .Fibrinogen gene polymorphism(rs1049636) were genotyped by using PCR‐LDR assay .Results γ′fibrinogen concentrations in IS patients[(159 .4 ± 97 .4)U/dL] were significantly higher than that in control group[(114 .2 ± 73 .0)U/dL] with statistically significant difference(P<0 .001) .Single nucleotide polymorphism(SNP) analysis showed that rs1049636 C allele was significantly associated withγ′fibrinogen level ,but not associated with increased risk of IS(P=0 .077) .Conclusion An associ‐ation between increasedγ′fibrinogen level and IS existed in Chinese Han population .However ,no association between rs1049636 C allele and IS risk was observed in our study .
