Effect of sodium valproate,topiramate on cognitive function of epileptic children of school age and their comparative analysis

VernacularTitle:丙戊酸钠、托吡酯对学龄期癫痫患儿认知功能的影响及对比分析
Author: Jing WANG ; Xinyi XU
Publication Type:Journal Article
Keywords: epilepsy; sodium valproate; topiramate; cognitive function
From: International Journal of Laboratory Medicine 2015;(20):2956-2957,2960
CountryChina
Language:Chinese
Abstract: Objective To study the effect of sodium valproate ,topiramate on cognitive function of epileptic children of school age .Methods 58 cases of children with epilepsy were recruited in the study(epilepsy group) .58 patients were randomly divided in‐to two groups .Group A :30 cases ,treated with oral administration of sodium valproate .Group B:28 cases ,treated with topiramate . 36 cases of healthy children who underwent health examination during the same period in the hospital were recruited as control group .Cognitive function were assessed before and after treatment for children in epilepsy .Results VIQ ,PIQ ,FIQ of epilepsy group were lower than the control group(P<0 .05) .The VIQ ,PIQ ,FIQ of Group A did′t change significantly after treatment(P>0 .05) .The PIQ of Group B didn′t change significantly after treatment(P>0 .05) ,while VIQ and FIQ were lower after treatment than before treatment(P<0 .05) .Conclusion The side effect of sodium valproate is smaller on cognitive function of epileptic chil‐dren of school age and it is safer compared with topiramate .