ANA and anti-CCP detection in elderly patients with rheumatoid arthritis and their relationship with depression
10.3969/j.issn.1673-4130.2015.20.028
- VernacularTitle:老年类风湿性关节炎患者ANA和抗-CCP检测及其与抑郁的相关性
- Author:
Wenyi PEI
;
Haoming JIANG
;
Haiyan YUAN
;
Jian HOU
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
antinuclear antibodies;
anti-cyclic citrullinated peptide antibody;
depression;
elderly peo ple
- From:
International Journal of Laboratory Medicine
2015;(20):2987-2988,2991
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of antinuclear antibodies(ANA) ,anti‐cyclic citrullinated peptide antibody (anti‐CCP) in elderly patients with rheumatoid arthritis(RA) ,and analyze its relation with depression .Methods ANA ,anti‐CCP were detected in 58 elderly RA patients ,50 non‐RA and 50 healthy people .Self‐rating Depression Scale(SDS) was used to assess the incidence of depression .Results The positive rate of anti‐CCP in RA group was significantly higher than that in control group and non‐RA group(P<0 .05) ,while there was no significantly difference in positive rate of ANA compared between RA group and non‐RA group(P>0 .05) .The positive rates of anti‐CCP and ANA in active stage were significantly higher than those in stable stage(P<0 .05) .The positive rates of anti‐CCP and ANA in RA complicated with depression were significantly higher than those in RA without depression(P<0 .05) .Multiple linear regression analysis showed that positive rates of anti‐CCP and ANA were all in‐dependent influence factors of depression in elderly RA patients(P<0 .05) .Conclusion Anti‐CCP and ANA in elderly RA patients over express ,and the positive rates are positively related with disease activity and depression .
