Th1/Th2 imbalance in ischemia-reperfusion injury and the application prospects of traditional Chinese medicine with multi-target effect
10.3969/j.issn.1001-1978.2015.09.001
- VernacularTitle:Th1／Th2失衡与缺血／再灌注损伤及中药多靶点调节的应用前景分析
- Author:
Xuehong DENG
;
Xiaoyan XING
;
Guang LI
;
Meishuang ZHANG
;
Jinjin SHI
;
Guibo SUN
;
Xiaobo SUN
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion injury;
helper T cell;
Th1 /Th2;
immune response;
traditional Chinese medicine;
multi-target
- From:
Chinese Pharmacological Bulletin
2015;(9):1185-1188,1189
- CountryChina
- Language:Chinese
-
Abstract:
The damage of tissue increases dramatically after reperfusion of blood supply to ischemic tissues.Immune response is one of the key reasons of ischemia-reperfusion injury.Th1 /Th2 generally stays balanced in normal states.Under the envi-ronment of ischemia reperfusion,Th1 /Th2 shifting let Th1 domi-nant to mediate cellular immunity.Excessive immune reaction may cause cell apoptosis and tissue damage.Recent studies showed that induction of transferring Th1 dominant to Th2 domi-nant was feasible for the treatment of ischemia-reperfusion inju-ry.With the progress of modern drug development paradigm“multi-composition,multi-target”,Chinese medicine has advan-tages in treating complex diseases.This paper summarizes the research of the relationship between Th1 /Th2 imbalance and is-chemia-reperfusion injury,together with the prospects of tradi-tional Chinese medicine with multi-target effect in ischemia-reperfusion injury.
