Effects of resveratrol on astrocyte activation after cerebral ischemia/reperfusion injury in rats
10.3969/j.issn.1001-1978.2015.09.010
- VernacularTitle:白藜芦醇对大鼠脑缺血／再灌注损伤后星形胶质细胞活化的影响
- Author:
Pingping YU
;
Li WANG
;
Fanren TANG
;
Luling ZHOU
;
Li ZENG
;
Xiaosong SONG
;
Jixiang CHEN
;
Qin YANG
- Publication Type:Journal Article
- Keywords:
resveratrol;
cerebral ischemia;
reperfusion injury;
astrocyte;
neuron;
activation
- From:
Chinese Pharmacological Bulletin
2015;(9):1228-1232,1233
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of resveratrol on astrocyte activation after cerebral ischemia/reperfusion injury in rats.Methods 45 male Sprague-Dawley rats were divided into sham,control and resveratrol groups, 15 rats in each group.Resveratrol or solvent was intra-peritoneally perfused into the rats for 7 consecutive days after 3h for MCA I /R.Cerebral infarction volume with TTC,neurological function score with Longa score, and pathological change with HE staining,the protein expressions of Caspase-3 with immunohistochemistry at 24h after MCA I /R were examined.The protein ex-pressions of GFAP and NeuN in penumbra were detec-ted with immunohistochemistry and immunofluores-cence at 14d after MCA I /R.Results Resveratrol treatment significantly improved the neurological func-tion score,decreased the infarct volume,reduced neu-ron loss,and inhibited the activation and proliferation of astrocytes,compared with the control group.Con-clusion Resveratrol can inhibit the excessive activa-tion of astrocytes,protect neurons in penumbra and im-prove neurological function.
