Antidepressive-like effect of alcoholic extract of Polyrhachis vicina Roger
10.3969/j.issn.1001-1978.2015.09.020
- VernacularTitle:拟黑多刺蚁醇提物抗抑郁作用研究
- Author:
Guining WEI
;
Shifeng CHU
;
Hua SU
;
Fei HE
;
Qibiao SU
;
Wenjie LU
;
Guoshou LU
;
Zhoufeng HUANG
;
Xiao TAN
;
Xiao LIN
;
Xianbiao ZENG
;
Baowei WEI
;
Naihong CHEN
- Publication Type:Journal Article
- Keywords:
Polyrhachis vicina Roger;
depression;
mechanism;
5-hydroxytryptamine;
noradrenaline;
su-peroxide dismutase
- From:
Chinese Pharmacological Bulletin
2015;(9):1280-1285,1286
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the antidepressive-like effect of ethyl alcohol extract of Polyrhachis vicina Rog-er(EAPR),and its mechanism.Methods EAPR was prepared by ethanol extraction.Its anti-depressive effect was investigated by tail suspension test (TST) and forced swimming test (FST).Furthermore,repeated doses of reserpine was used for preparing the depres-sive rats.Results EAPR has definitely anti-depres-sive effect,as evidenced by the decreased immobility time in FST and TST at the doses of 8 and 4 g·kg -1 (P <0.05).In the repeated reserpine evoked depres-sive rats,EAPR antagonized the symptoms induced by monoamines depletion and attenuated the anhedonia, as manifested by reversed hypothermia,akinesia and sucrose consumption at the doses of 8 and 2 g·kg -1 (P <0.05,P <0.01).Neuro-chemical studies showed that AFPR significantly increased the concentration of monoamines,including 5-hydroxytryptamine (5-HT) and noradrenaline(NA)at the dose of 8 g·kg -1 (P <0.05),and had no effect on normal rats .Furthermore, EAPR increased the activity of superoxide dismutase (SOD)in serum,hippocampus and cerebral cortex at the dose of 8 g·kg -1 (P <0.05).Conclusion EA-PR possesses the definite antidep ressive properties, connected with the regulation of neurotransmitter me-tabolism and the nerve cells antioxidant effect.
