Research advance of tumor necrosis factor receptor-associated factors in inflammatory immune regulation
10.3969/j.issn.1001-1978.2015.09.006
- VernacularTitle:肿瘤坏死因子受体相关因子参与炎症免疫调节的研究进展
- Author:
Ying LI
;
Jingyu CHEN
;
Lingling ZHANG
;
Wei WEI
- Publication Type:Journal Article
- Keywords:
TRAF;
signal transduction;
TNFR;
NF-κB;
immuni-ty;
inflammation;
diseases
- From:
Chinese Pharmacological Bulletin
2015;(9):1206-1210,1211
- CountryChina
- Language:Chinese
-
Abstract:
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF )is an important of multifunctional intracellular signal transduction factors.TRAFs involve in signal transduction of many receptor families,including TNF receptor family (TN-FR),Toll-like receptors interleukin-1 receptors (TLR-IL-1R) family and so on.TRAFs play important roles in innate immunity and acquired immunity.TRAFs could directly or indirectly re-cruit the intracellular domains of receptors in the condition of ac-tivated receptor,which leads to the activation of transcription factors,such as NF-κB and interferon-regulatory factor (IRF), through signaling pathway.And TRAFs ultimately induce im-mune and inflammatory responses and involve in the development of inflammatory autoimmune diseases.
