The significance of detecting serum DJ-1 protein combined with CA125 in epithelial ovarian tumors
10.11958/j.issn.0253-9896.2015.11.022
- VernacularTitle:联合检测血清DJ-1和CA125在上皮性卵巢肿瘤中的意义
- Author:
Weiming WANG
;
Zhihui CAI
;
Jin LIU
;
Yijuan LIANG
;
Youju MA
;
Hui LIU
- Publication Type:Journal Article
- Keywords:
CA-125 antigen;
ovarian neoplasms;
diagnosis;
ROC curve;
DJ-1
- From:
Tianjin Medical Journal
2015;(11):1304-1306,1307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of detecting serum DJ-1 protein combined with CA125 for epi?thelial ovarian tumors. Methods Double antibody sandwich method and electrochemiluminescence immunoassay were used to determine the serum levels of DJ-1 protein and CA125 in 82 cases of epithelial ovarian tumors and 80 non-ovarian tumor cases (control group). The clinical significance of detecting serum DJ-1 protein combined with CA125 was analyzed. Results The expression levels of DJ-1 and CA125 were significantly higher in ovarian tumor group than those in the con?trol group (P<0.05). The critical value of serum DJ-1 was 6.800μg/L and 6.965μg/L in ovarian cancer group compared with the control group and non-ovarian tumor group. The sensitivity of combined detection of DJ-1 and CA125 was higher than that of any marker alone. Conclusion The detecting serum levels of DJ-1 combined with CA125 are helpful to the diagnosis of ovarian cancer, which can be a good marker of ovarian cancer and may improve the early diagnosis rate of ovarian cancer.