Noninvasive Detection of Liver Fibrosis by Fibroscan in Asymptomatic Carriers with Chronic Hepatitis B Virus

VernacularTitle:Fibroscan 无创检测慢性乙型肝炎病毒携带者肝纤维化的临床意义
Author: Hongfang DING ; Ke MA ; Qin NING
Publication Type:Journal Article
Keywords: chronic hepatitis B carriers; fibroscan; liver biopsy
From: Acta Medicinae Universitatis Scientiae et Technologiae Huazhong 2015;(5):572-574,590
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical application of Fibroscan to noninvasive detection of liver fibrosis in asymp‐tomatic carriers(ASCs)with chronic hepatitis B virus(HBV).Methods Clinical data of 195 chronic HBV ASCs were retrospec‐tively analyzed ,including liver function ,HBV DNA quantitation ,liver stiffness(LS) ,color Doppler ultrasound results of the liver and spleen and histopathological findings of the liver.LS was evaluated by transient elastography(Fibroscan).Liver biopsy was performed in 80 carriers for histological examination.Results The LS value was(6.22 ± 2.50)kPa in 195 cases.There was no significant difference in the LS value between HBV DNA <500 copies/mL and HBV DNA≥500 copies/mL groups.The LS value in patients with HBV carrying duration>15 years was significantly higher than that in patients with HBV carrying dura‐tion≤5 years(P<0.01).It was (6.72 ± 2.33) kPa in patients(n=49)with liver tissue inflammation and necrosis