The impact of metoprolol and tongxinluo on the levels of serum hs -CRP and NT -proBNP in patients with ;coronary heart disease
10.3760/cma.j.issn.1008-6706.2015.21.025
- VernacularTitle:美托洛尔联合通心络对冠心病心功能不全患者血清超敏 C 反应蛋白及血浆 N 末端 B 型钠尿肽原水平的影响
- Author:
Wei LIN
;
Haiyan YANG
- Publication Type:Journal Article
- Keywords:
Metoprolol;
Tongxinluo;
Coronary heart disease;
C -reactive protein;
B -type natriuretic peptide
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(21):3280-3282,3283
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of metoprolol and tongxinluo on the levels of hypersensitivity C -reactive protein (hs -CRP)and NT -proBNP in patients with coronary heart disease.Methods 84 patients with coronary heart disease were randomly divided into the observation group(n =42)and the control group(n =42). The control group was given metoprolol treatment,and the observation group was given metoprolol and tongxinluo treat-ment for 3 months.The echocardiography before and after treatment was inspected.The levels of serum hs -CRP were measured with immune reflection method and the levels of BNP were measured with ELISA.Results The total effective rate,adverse reaction rate of the control group were 95.24%,4.76%,and those of the observation group were 76.19%,23.81%,the differences were statistically significant (P <0.05).The ventricular septal thickness (IVST),left ventricular ejection fraction (LVEF),left ventricular end diastolic diameter (LVDD),left ventricular systolic touch the inside diameter (LVSD)of the observation group were improved than the control group (P <0.05),while the IVST,LVEF,LVDD,LVSD of the observation group after treatment were better than the control group (t =3.996,4.123,3.852,4.256,all P <0.05).The levels of serum hs -CRP and NT -proBNP of the observation group were lower than the control group (t =5.225,7.856,all P <0.05).Conclusion Metoprolol combined with Tongxinluo capsule can improve cardiac function,reduce serum hs -CRP and plasma BNP levels,improve clinical outcomes of patients.
