Clinical efficacy of theophylline combined with tiotropium dry powder in the treatment of stably chronic ;obstructive pulmonary disease
10.3760/cma.j.issn.1008-6706.2015.21.030
- VernacularTitle:茶碱缓释片联合噻托溴铵干粉治疗稳定期慢性阻塞性肺疾病的疗效观察
- Author:
Zhijie LI
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Lung function;
Theophylline;
Tiotropium
- From:
Chinese Journal of Primary Medicine and Pharmacy
2015;(21):3296-3298,3299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical efficacy of theophylline combined with tiotropium dry powder in the treatment of stably chronic obstructive pulmonary disease (COPD).Methods 140 patients with stable COPD were divided into the study group and control group according to the random number table method,70 patients in each group.The control group was treated with theophylline,while the study group was treated with theophylline combined with tiotropium dry powder.The quality of life was evaluated by quality of life scale(QLC),the exercise tolerance was estimated by 6min walk distance(6MWD),and the forced expiratory volume in one second(FEV1 ),FEV1 /forced vital capacity(FVC),matrix metalloproteinase enzyme -9(MMP -9)and interleukin -8(IL -8)were detected in two groups before and after treatment.The adverse reactions of two groups were compared.Results After treatment, FEV1 ,FEV1 /FVC of the two groups were (1.49 ±0.04)L,(3.21 ±56.02)% and (1.89 ±0.21 )L,(59.98 ± 2.09)% respectively,which were significantly better than before treatment(t =7.98,9.03,8.03,8.32,all P <0.05),and which of the study group after treatment were significantly better than the control group(t =7.21,8.23,all P <0.05).6MWD and QLC after treatment of the two groups were (301.19 ±18.08)m,(67.19 ±2.31)points and (342.89 ±8.07)m,(75.21 ±5.25)points,which were significantly better than before treatment(t =7.98,8.03, 7.28,7.43,all P <0.05),and which of the study group after treatment were significantly better than the control group (t =8.03,8.47,all P <0.05).MMP -9 and IL -8 levels of two groups after treatment were (524.58 ±7.02)ng/mL, (7.23 ±1.04)ng/mL and (419.26 ±6.39)ng/mL,(6.09 ±0.06)ng/mL,which were significantly better than before treatment(t =7.52,8.13,7.23,7.41,all P <0.05 ),and which of the study group after treatment were significantly better than the control group(t =8.45,8.91,all P <0.05).The difference of adverse reactions of two groups was not statistically significant(χ2 =2.13,P >0.05).Conclusion Theophylline combined with tiotropium dry powder has an exact efficacy in the treatment of stable COPD,which can improve the lung function and the quality of life of patients.
