Omeprazole and Cimetidine for Stress Ulcer Bleeding Prophylaxis:A Meta-analysis
- VernacularTitle:奥美拉唑与西咪替丁预防应激性溃疡出血的Meta分析
- Author:
Yang LU
;
Sun LULU
- Publication Type:Journal Article
- Keywords:
Omeprazole;
Cimetidine;
Medication prophylaxis;
Stress ulcer;
Meta-analysis
- From:
China Pharmacist
2015;(11):1925-1927,1977
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of omeprazole and cimetidine in the prophylaxis of stress ulcer bleeding to provide evidence for clinical therapy in China. Methods:The randomized controlled trials were searched in PubMed, Medline, CNKI, Wan-fang and Vip database with the key words of omeprazole, cimetidine and stress ulcer. Two evaluators assessed the quality and reviewed the data independently. RevMan 5. 2 software was used for Meta-analysis. Results:Seventeen randomized controlled trials were includ-ed involving 892 patients for omeprazole group and 888 patients for cimetidine group. The results of Meta-analysis showed that the difference between the two groups after the treatment was statistically significant by comparing the incidence of stress ulcer bleeding (OR=0. 23,95% CI:0. 17-0. 32;P<0. 000 01). The incidence of stress ulcer bleeding of omeprazole group was significantly lower than that of cimetidine group. Conclusion:Existing literature analysis shows that omeprazole is more effective than cimetidine in the stress ulcer bleeding prophylaxis.
