Expression and correlation of Cx43 and E-cad in esophageal carcinoma
10.13315/j.cnki.cjcep.2015.10.005
- VernacularTitle:食管组织中Cx43和E-cad的表达及其相关性分析
- Author:
Yonghui DI
;
Jie MIAO
- Publication Type:Journal Article
- Keywords:
esophageal neoplasms;
Cx43;
E-cad;
immunohistochemistry;
Western blot
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(10):1099-1101,1106
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of the Cx43 and E-cad protein in esophageal carcinoma and normal esophageal tis-sue and to discuss their relationship. Methods SP immunohistochemical and Western blot analysis were used to detect the expression of Cx43 and E-cad in esophageal carcinoma and normal esophageal tissue. The relation between their expression and esophageal carci-noma was investigated. Results Immunohistochemical assay and Western blot analysis showed the expression levels of Cx43 and E-cad in esophageal carcinoma were significantly lower than that in normal esophageal tissue. The expression of Cx43 had correlation with lymph node metastasis. The expression of E-cad had correlation with degrees of pathological differentiation. There was a positive rela-tionship between the expression of Cx43 and E-cad in same sample. Conclusion Expression of Cx43 and E-cad protein is low in e-sophageal carcinoma, which can be helpful in the prediction of the biological behavior and prognosis of esophageal carcinoma.
