Expression of EphA1 protein in clear cell renal cell carcinomas and its clinical significance
10.13315/j.cnki.cjcep.2015.10.009
- VernacularTitle:肾透明细胞癌中EphA1蛋白的表达及临床意义
- Author:
Xiao CHEN
;
Xue WEI
;
Rusong ZHANG
;
Henghui MA
;
Zhenfeng LU
;
Jiandong WANG
- Publication Type:Journal Article
- Keywords:
renal neoplasms;
clear cell carcinoma;
EphA1;
receptor tyrosine kinase;
Fuhrman nuclear grade
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(10):1115-1117,1122
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of EphA1 in renal cell carcinomas ( RCC) and to analyze its correlation with clini-copathological parameters in order to explore the clinical significance of EphA1 protein in renal cell carcinomas ( RCC) . Methods The immunocytochemical method was employed to measure the expression of EphA1 in 144 clear cell RCC ( ccRCC) tissues, 18 chro-mophobe RCC tissues and 6 papillary RCC tissues. Correlation between EphA1 protein expression and clinical parameters was evaluated by statistics. Results High level of the expression of EphA1 was observed in all normal renal tubes. The EphA1 protein was negative-ly or weakly expressed in 93 out of 144 ccRCC (64. 6%) and positively expressed in 51 out of 144 ccRCC (35. 4%). Positive expres-sion of EphA1 was observed in all samples of chromophobe RCC and papillary RCC. The high level expression of the EphA1 protein was significantly associated with younger patients (P<0. 001), sex (P=0. 016) and lower nuclear grade (P<0. 001). No significant relation between the expression of EphA1 and tumor diameter was found ( P=0. 316 ) . Conclusion EphA1 protein may be a new marker for the prognosis of ccRCC.
