Effect of dietary fat acids on incretin and islet function
10.7644/j.issn.1674-9960.2015.10.009
- VernacularTitle:不同类型脂肪酸饮食对肠促胰岛素及胰岛功能的影响
- Author:
Zhe GAO
;
Xiaolu YAN
;
Guangyao SONG
;
Huijuan MA
;
Chunxia DONG
- Publication Type:Journal Article
- Keywords:
glucagon-like peptide-1;
gastric inhibitory polypeptide;
saturated fat acid;
monounsaturated fat acid
- From:Military Medical Sciences
2015;(10):769-772,786
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of dietary fat acids on incretin and islet function in healthy adults .Methods Before each test, healthy subjects received a 1-week pre-experiment eucaloric diet .Fifteen subjects consumed two meals containing different fat acids , including high saturated fat acid ( HSF) and high monounsaturated fat acid ( HMF) .On two separate occasions,they underwent a minimum of 1-week washout between meals .At 0,30,60,120,180 and 240 min following meal intake, the plasma concentrations of gastric inhibitory polypeptide (GIP), glucagon-like peptide-1(GLP-1) and serum concentrations of glucose, insulin, triglycerides ( TG) and free fatty acid ( FFA) were measured.Results Postprandial glucose did not increase significantly following HSF and HMF meals (P>0.05).Compared with HMF meal, significant increase in AUCins240min,AUCTG240min and AUCFFA240minwas observed following HSF meal (P<0.05).Compared with HMF meal,a significant decrease in AUCGIP30min, AUCGIP240min, AUCGLP-1 30min and AUCGLP-1 240min was found following HSF meal (P<0.05).No significant difference was observed inΔI30/ΔG30 following HSF and HMF meals (P>0.05). AUCI/AUCG was significantly lower following HMF meal as compared with HSF meal (P<0.05).Conclusion This study demonstrates that the function of GIP ,GLP-1 andβcell is affected by the dietary fat acids in healthy adults .The HMF meal may stimulate GIP and GLP-1 secretion to a greater extent than HSF meal .
