Research progress on tumor ECM fibrogenesis in tumor metastasis

VernacularTitle:肿瘤ECM纤维生成与肿瘤转移研究进展
Author: Peiliang SHEN ; Zhaoguo LIU ; Xu WANG ; Ying SHEN ; Hongyan WU ; Pingting ZHU ; Wenxing CHEN ; Aiyun WANG ; Yin LU
Publication Type:Journal Article
Keywords: tumor; ECM fibrogenesis; tumor metastasis; cyto-kines; molecular mechanisms; therapy strategies
From: Chinese Pharmacological Bulletin 2015;(11):1485-1487,1488
CountryChina
Language:Chinese
Abstract: Tumor metastasis is one of the most important biologi-cal characteristics of malignant tumor, and it is also the main factor resulting in poor prognosis and leading to failure of treat-ment. In recent years, studies have shown that the extracellular matrix ( ECM) of tumor microenvironment plays a critical role in tumor metastasis. Tumor ECM fibrogenesis could form the cross-linked network structure, which not only provides nutrition and support to tumor, also it is necessary to tumor growth and inva-sion. These research results indicate that blocking ECM fibro-genesis may exert an inhibitory effect on tumor metastasis. Therefore, targeting ECM fibrogenesis has become a particularly attractive strategy as it can be used in the treatment of metasta-sis-related diseases. The ECM fibrogenesis in tumor is reviewed in this paper as well as the treatment strategies on tumor metas-tasis by targeting ECM fibrogenesis, which may provide refer-ences for follow-up research and clinical treatment.