Progress on functions of lateral habenula and related mechanisms
10.3969/j.issn.1001-1978.2015.11.006
- VernacularTitle:外侧缰核功能及相关机制研究进展
- Author:
Rui YAO
;
Junli CAO
- Publication Type:Journal Article
- Keywords:
lateral habenula;
drug addiction;
behavioral avoid-ance;
reward-aversion;
depression;
pain;
cognitive function and emotion
- From:
Chinese Pharmacological Bulletin
2015;(11):1502-1504,1505
- CountryChina
- Language:Chinese
-
Abstract:
Lateral habenula ( LHb ) , which is situated in the dorsal diencephalon of all vertebrates, is an important component of the habenular complex. The neural network outlined in previ-ous studies indicates that LHb acts not only as an important relay station to link the forebrain with the midbrain regions that in-volved in regulating behavioral responses to reward and mediating the transmassion of negative feedback information, but also is closely connected with 5-HT system. Indeed, recently studies demonstrate that experimental manipulations of LHb are followed by behavioural alterations in relation to drug addiction, reward-a-version responses, pain, sleep, depression and so on. This arti-cle mainly reviews the mechanisms of LHb involved in all kinds of physiological activities.
