Establishment and evaluation of intravascular thrombosis used for cerebral embolism model

VernacularTitle:血管内成栓脑梗死模型的制备及评价
Author: Yinzhong MA ; Guanhua DU
Publication Type:Journal Article
Keywords: ischemic stroke; stroke; cerebral ischemia; cere-bral embolism; thrombus model; stroke model
From: Chinese Pharmacological Bulletin 2015;(11):1620-1622,1623
CountryChina
Language:Chinese
Abstract: Aim To produce cerebral embolism rat model via in-travascularly formed thrombus. Methods Thrombus was formed in common carotid artery ( CCA ) by constant galvanic stimulation, then it was shattered and MCA was occluded. To i-dentify the feature of the model, focal cerebral blood flow ( CBF ) , cerebral infarction volume and behavior tests were measured. Thrombolysis with tissue plasminogen activator ( tPA) were observed. Results This model developed a reduction of blood flow (30% of baselines) within the MCA territory. Signifi-cant infarction and neurological disorder were observed 24 h after the embolism onset. Thrombolysis with tPA ameliorated the path-ological process which was mentioned above. Conclusion Cer-ebral embolism model induced by intravascular formed thrombus in rat is suitable for the research of pathology and thrombolytics for embolic stroke.