The regulatory mechanisms of P-glycoprotein in leukemia of multi-drug resistance
10.3760/cma.j.issn.1673-4408.2015.05.005
- VernacularTitle:P糖蛋白在白血病多药耐药中的调控机制
- Author:
Jieru CHEN
- Publication Type:Journal Article
- Keywords:
P-glycoprotein;
Leukemia;
Multi-drug resistance
- From:
International Journal of Pediatrics
2015;42(5):499-502,506
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistance (MDR)has been a main reason for the failure of leukemia chemotherapy.The generation of MDR in leukemia is directly related to the transportation of drug efflux of P-glycoprotein (P-gp)on cell membrane surface.Many signaling pathways such as MAPK、NF-κB、Hedgehog、Wnt/β-catenin、 and PI3K/Akt involves in regulating of P-gp expression.Meanwhile, regulation factors including Stats、 microR-NA、TRAIL and HDACs are closely related to the P-gp expression.This review briefly discusses the progress of the regulatory mechanisms of P-gp in MDR of leukemia.
