Advances and enlightenment of myeloproliferative neoplasms associated gene mutations in thrombophilia and general population
10.3760/cma.j.issn.1009-9921.2015.07.008
- VernacularTitle:易栓症患者及总体人群中骨髓增殖性肿瘤相关基因突变研究进展及启示
- Author:
Xue CHEN
;
Yang ZHANG
;
Hongxing LIU
- Publication Type:Journal Article
- Keywords:
Myeloproliferative neoplasms;
Thrombophilia;
JAK2;
CALR
- From:
Journal of Leukemia & Lymphoma
2015;24(7):412-414,419
- CountryChina
- Language:Chinese
-
Abstract:
The detection of JAK2 V617F and CALR mutations,which was first reported in 2005 and 2013,respectively,had greatly improved the diagnosis and treatment of myeloproliferative neoplasms (MPN).Most MPN patients are inclined to thrombophilia,the carrier frequency of JAK2 V617F mutation was also high in patients of various thrombotic events,and the relationship between the two conditions needs further study.The observation of JAK2 V617F mutation in control group and general population also enlightened and changed the understanding about the development of chronic cancer.Research progress in this area will be introduced together with the related reports in the 56th American Society of Hematology annual meeting in 2014.
