The change of serum TK1 level in the treatment process of the early cure nasopharyngeal carcinoma patients and its relationship to pathological features
10.3969/j.issn.1671-8348.2015.32.025
- VernacularTitle:血清胸苷激酶-1水平在鼻咽癌患者治疗过程中的动态变化及与病理学特征的关系
- Author:
Jun LI
;
Qiuling SONG
- Publication Type:Journal Article
- Keywords:
thymidine kinase;
nasopharyngeal neoplasms;
pathology
- From:
Chongqing Medicine
2015;(32):4532-4534,4537
- CountryChina
- Language:Chinese
-
Abstract:
Objective To learn the change of serum thymidine Kinase 1(TK1) level in the treatment process of the early cure nasopharyngeal carcinoma patients and its relationship to pathological features .Methods From January 2010 to December 2013 ,35 cases of nasopharyngeal carcinoma patients were collected into our study ,20 cases of nasopharyngeal inflammation patients were chosen as the control .Serum TK1 level in the 2 groups was compared before and after treatment .Results TK1 in control group had no significant differences before and after treatment (P>0 .05) .Compared with the control group ,serum TK1 in nasopharyngeal carcinoma group were higher before and after radiotherapy (P<0 .05);after radiotherapy ,serums TK1 in nasopharyngeal carcinoma group were lower(P<0 .05) .Before and after radiotherapy ,serum TK1 Ⅰ and Ⅱ stage were lower than in Ⅲ and Ⅳ stager(P<0 .05) ,lymph node metastasis group were higher than no lymph node metastasisr (P<0 .05) ,TK1 had higher expression in TNMⅣ than TNM Ⅱ(P<0 .05) ,compared with lymph node metastasis and cervical nerve violated groups ,TK1 expression was higher in none lymph node metastasis and none cervical nerve violated groups (P<0 .05) .Conclusion TK1 can reflect the tumor load and proliferative activity of nasopharyngeal carcinoma ,which could be as a factor in nasopharyngeal carcinoma diagnosis ,monitoring and prognosis .
