Effects of lactobacillus on the histamine,IL-5,IL-12 in serum and ICAM-1 in tissue of the allergic rhinitis rat model
10.3969/j.issn.1671-8348.2015.31.020
- VernacularTitle:嗜酸乳酸杆菌对过敏性鼻炎模型大鼠血清中组胺、IL-5、IL-12及组织中ICAM-1的影响
- Author:
Haichao CHI
;
Mi CHEN
;
Jie ZHANG
- Publication Type:Journal Article
- Keywords:
rhinitis allergic;
interleukin-5;
interleukin-12;
cell adhesion molecules-1
- From:
Chongqing Medicine
2015;(31):4379-4381,4385
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of lactobacillus on serum histamine ,interleukin‐5(IL‐5) ,interleukin‐12(IL‐12) and tissue intercellular cell adhesion molecule‐1(ICAM‐1) on the rats of allergic rhinitis model .Methods Totally 48 male SD rats were randomly divided into control group ,model group ,Lactobacillus (LBA) group (1 × 1010 CUF/kg) and loratadine (LRD) group (5 mg/kg) ,there were 12 SD rats in each group .LBA Group administered once daily for a total of 6 weeks ;LRD group administered once daily for seven days .Then the clinical symptoms indexes ,the content of serum histamine ,IL‐5 ,IL‐12 ,the changes of tissue pathological ,the mRNA and protein of ICAM‐1 were compared .Results Lactobacilli can significantly improve symptoms score of allergic rhinitis in rats ,the pathological score ,reduce serum histamine ,IL‐5 levels ,ICAM‐1 mRNA and protein expression of tissue , and increase IL‐12 proportion ,thus it showed significant efficacy .Conclusion Long‐term (approximately six weeks) given lactoba‐cilli played a therapeutic role of allergic rhinitis by reducing serum histamine ,IL‐5 levels and ICM A‐1 expression in tissues ,in‐creased serum IL‐12 level .
